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KMID : 0882420080750030362
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Korean Journal of Medicine
2008 Volume.75 No. 3 p.362 ~ p.366
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Agranulocytosis due to secondary exposure to antithyroid drugs in a relapsed Graves’ disease patient
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Jeong Gwi-Hong
Kim Sung-Kyun
Myung Dae-Sung
Chung Jin-Ook
Cho Dong-Hyeok
Chung Dong-Jin
Chung Min-Young
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Abstract
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Antithyroid drugs are the most common treatment modality for Graves’ disease and are used for the treatment of relapsed Graves’ disease in Korea. Agranulocytosis is a rare and severe complication of antithyroid drug therapy, and most cases occur within 3 month after drug treatment. Agranulocytosis can develop in patients who have relapsed Graves’ disease and undergo a second course of antithyroid drugs with a prior uneventful course of drug therapy.
We report a case of antithyroid drug-induced agranulocytosis in a relapsed Graves’ disease patient who had undergone prior uneventful antithyroid drug therapy. We also present a review of the relevant literature.
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KEYWORD
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Graves’ Disease, Recurrence, Antithyroid agents, Agranulocytosis
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